I have a similar problem, the intel port two on the back and internal connected to frontpanel works perfectly for me but the four via:s at the backpanel causes freexing of the mouse for 1-3s every few minutes. Also my external dac/amplifier will not play smooth if i connect it using the via:s ports. Since i need three functiona usb ports in the back for keyboard mouse and audio dac this is a big issue for me. My WD usb drive works as expected on the via ports no stuttering during video playback from external drive, and decent HDtach results of 90MB/S. All devices appear correctly installed when exploring device manager and no errors in the event viewer. I tried removing all via drivers in the task manager including delete files, and reinstalling before using the via port but this did not help. I will try to RMA this board as the VIA compatability issue is just too annoying. This brings memorys up from the trublesome via 4in1 driver of past MB. I dont know if it is hardware related or software but this does not matter since the MB has been on the market for some months so software problems should have been fixed by now.