It depends on whether the user will use the hard drive as a data drive or a boot drive. A data drive requires an OS that supports long LBA addressing such as Windows 7, Linux Ubuntu or Apple Mac OS X with a GUID partition table (GPT). For a Windows boot drive, the aforementioned are required, plus the user will need a motherboard with a Unified Extensible Firmware Interface (UEFI) BIOS and appropriate storage drivers. Since the GA-MA69VM-S2 has no UEFI BIOS you only have the data drive as a possible option.