Last night I had an issue with an OC setting not wanting to boot.  
I thought "no big deal I will clear CMOS".  I went to clear the CMOS and nothing happened.  I tried a few more times, and nothing.  I had to pull the battery for 30 seconds.  To get defaults to load.  That has never happened.
Here is the next problem I had.  Once I had cleared the CMOS, I went into the BIOS and got my settings how I wanted them.  I saved the BIOS, then rebooted and went back into the BIOS so I could power the machine down. (I have performance ram that wont boot on defaults).  For the past five years, I have been able to press the power button on the case to power down when I am in the BIOS.  Now when I press it, the screen goes black but the machine stays ON.  This causes the BIOS to go haywire and need a reset.   And then I have to pull the battery and wait 30 seconds again.
The other thing I tried is to power the machine down while in the BIOS with the power switch, and guess what?  IT MAKES THE BIOS NEED A RESET.
I have flashed the BIOS, and it still behaves this way.  Is this board done?  I have never had an issue like this with any board over the years.  I plan on ripping the whole thing out of the case tonight and trying it barebones with a different PSU to see if that may have some effect.