When you go from automatic to manual, settings such as timing voltages, multipliers, etc become unlinked (generally speaking). However, we've seen issues where some settings remain tied to one another for no apparent reason. The information in my last post should allow you to use manual setting for the RAM, (disable XMP) and set in M.I.T. section of BIOS. Be conservative and you won't hurt anything. In these situations, "less is always more".