I have the same problem
PottyPete,it has nothing to do with gfx card drivers or the operating system,it is a BIOS/self check problem related to specific Radeon 4890's
With mine it causes a longer POST time and fails POST with a double boot when any FSB,Memory timings etc are changed from Auto to manual in the M.I.T
Basically what happens is,with the R4890 plugged in it will fail a POST with a double reboot whenever certain changes are made in the M.I.T section of the BIOS.It will not tolerate virtually any timing changes or settings taken off AUTO control, apart from some voltage changes (eg DDRAM voltage).Even enabling manual FSB control causes a double reboot,even if the FSB is inputted/left at standard.You can change to a lower multiplier (underclock CPU ) but no FSB changes ,even when it is set manual instead of Auto with default CPU FSB.Same thing with Ram timings or FSB to Ram multiplier.On re-entering the BIOS after a double reboot then going into M.I.T part of BIOS it says something like "your sytem has failed to boot due to voltage or overclocking",but it still does this even if you make changes in there to default settings ie take certain settings off Auto or manually set FSB by keying in value.
When i was using a Radeon HD4850 I had a reliable overclock to 3.6GHZ with 1:1 ratio ,400mhz FSB ,ram timings manually set to 4-4-4-12.No BIOS voltage tweaks required
This was with pairs of mismatched memory modules as well (2x PC6400C4 and 2xPC8500C5') set to 800mhz
Since installing an MSI R4890 Cyclone OC it has a longer POST time (when it boots with stock/ std settings ie F7 optimised defaults)
Now it will also not tolerate any changhes in the M.I.T bios section
Here is a link to same type of problem in another forum
http://forums.ncix.com/forums/?mode=showthread&forum=101&threadid=2061883&pagenumber=1&subpage=1My system specs are Gigabyte EP45-DS3R motherboard F10 bios (also tried F11c)
Core 2 Duo E8400
MSI Radeon R4890 Cyclone OC gfx card (was ok with Saphire HD4850 or Gigabyte HD4850)
Currently 2Gig of Corsair PC8500
Hyper type R 580watt PSU
Martin