I have the same ram as you in the gigabyte x99p sli, F21 works with this memory, HOWEVER... U cant use XMP1, well I cant, I get several restarts and eventually a bios error. I was told to try F22I which claims to add support to more DDR4, but as soon as Windows 10 booted up, desktop loaded, BSOD every time, unrecoverable error, something like that, had to go back into bios and flash F21. So if u do update the bios, make sure u have F21 ready for any problems...