I would say more likely NO. But I have seen where newer video cards work in older board. A couple things here are that the board & CPU don't support 3.0 cards. Yes you can take a chance on buying it and trying it.
But if doesn't work, then you will have upgrade the mother board & CPU. If you look for a good Ati 5800, 6900 series & nvidia 500, 600 series card you will have better change at it working. Plus get the full performance out of those cards vs the 750.