GA-Z170-Gaming K3 EU - PSU Noise when gaming

[Stormblade]

I have a GA-Z170-Gaming K3 EU motherboard, and I am getting a lot of noise from the PSU when running games.
The noise is like a squeal that changes pitch/pattern depending on what the game is doing.

Full system specs...
gigabyte-ga-z170-gaming-k3
intel-core-i7-6700k-s-1151-skylake
32gb-(2x16gb)-corsair-ddr4-vengeance-lpx-black-pc4-24000
850w-corsair-cx850m-hybrid-modular-80-plus-bronze
512gb-samsung-sm951-m2-(22x80)-pcie-30-(x4)-nvme-ssd
geforce-gtx-1080-founders-edition-8gb

I have tried 3 different PSUs, 2 other graphics cards, and the on-board graphics, a different hard drive.
I've tried disabling Eist, C1 and all the other power saving options.
I've tried enabling Load-Line Calibration
Forcing V-Sync enabled helps a little in some games, but not much.
I have RMA'd the motherboard once, and received a replacement the same model, and the problem is still there.

Is there anything else to try before I RMA this one as well, and try a different make/model?

[shadowsports]

Is this coil whine?  Seems you've changed a bunch of the hardware and tried different configurations without luck.  Are you over clocking your CPU or memory?  The GTX 1080 should handle anything you throw at it.

[dmdilks]

I had a corsair that did the same thing. But I gone was a louder fan noise. Some of the corsair will speed up and down what load you put on them. I would email corsair and ask them. If it is still under warranty they should replace it.

[LateDev]

I have a GA-Z170-Gaming K3 EU motherboard, and I am getting a lot of noise from the PSU when running games.
The noise is like a squeal that changes pitch/pattern depending on what the game is doing.

Full system specs...
gigabyte-ga-z170-gaming-k3
intel-core-i7-6700k-s-1151-skylake
32gb-(2x16gb)-corsair-ddr4-vengeance-lpx-black-pc4-24000
850w-corsair-cx850m-hybrid-modular-80-plus-bronze
512gb-samsung-sm951-m2-(22x80)-pcie-30-(x4)-nvme-ssd
geforce-gtx-1080-founders-edition-8gb

I have tried 3 different PSUs, 2 other graphics cards, and the on-board graphics, a different hard drive.
I've tried disabling Eist, C1 and all the other power saving options.
I've tried enabling Load-Line Calibration
Forcing V-Sync enabled helps a little in some games, but not much.
I have RMA'd the motherboard once, and received a replacement the same model, and the problem is still there.

Is there anything else to try before I RMA this one as well, and try a different make/model?

You have not said which other PSU's you have tried.
I had a coolermaster PSU which is fairly noisy (now my second computer for work) and baring that in mind I purchased a be quiet Pure Power and the difference is astounding. Noisiest fan is the graphics card when it ramps up on speed for cooling.

The fan on my network drive bay is loder than the computer.

The sound you are talking about can be anything but usually if it is not a fan ramping up on speed, the laminations of the PSU coils start to make a noise when they are stressed, this is just a resonance set up by the switch mode supply when the PSU is being over worked. However the PSU you have is complete overkill based on your published components, and of course is not actually running very efficiently.

Most noise is generated from fans unless you can actually pin point where the sound is coming from. I doubt very much that the Mobo is the culprit and would be looking at the PSU or fans.

[shadowsports]

The OP did say he tried with 3 different PSU's.  I find it hard to believe all 3 would have coil whine, if this is on fact what he's experiencing. The cx-850m is pushing 70 amps on the 12v rail.  Cards requirements are 500w min and card pulls 180w at full load.

I agree with LateDev in regards to the source of the issue.  I don't think its your board.  Use a paper towel roll to figure out what the noise is and where it is coming from.   
 
I like corsair products.  I use Corsair memory and PSU's exclusively.  Have for years.  All models above the CS series support Zero RPM Fan Mode.  The fan doesn't run unless a thermal threshold is reached.  I love this feature as the PSU fan never turns on unless I game or render video.  Lots of other good products out there, but I've had good luck with corsair and am partial.