Try using 3 slots.
Did that when I hit the problem and the PC does no reach POST (no deep codes) with three slots in use.
Just to re-iterate:
Original set up - 2 X 4GB CMX8GX3M2A133C9 in white slots boots, never any problems with BIOS default memory settings.
Add 2 X 4GB CMX4GX3M1A133C9 to blue slots. PC doesn't reach POST. PC fails to boot with four slots occupied - all possible variations tried.
With just any two memory slots occupied the PC boots. These combos all work:
2 X 4GB CMX8GX3M2A133C9
2 X 4GB CMX4GX3M1A133C9
1 X 4GB CMX8GX3M2A133C9 + 1 X 4GB CMX4GX3M1A133C9
The last combo was accidentally used and would imply a mix of the two types of memory modules do work together.
This PC is in constant daily use and a future attempt to get 4 X 4GB to work will have to wait for a day or two. Planned test is to start with the two 4GB CMX4GX3M1A133C9 memory sticks in the white slots, boot and enter BIOS to check the default auto memory settings. Boot Windows ( not my normal OS) to use CPU-Z to check JEDEC/XMP profiles and see if there is an XMP profile at 1.6volts. Re-boot and bump DRAM voltage to 1.55V, save & exit and shutdown. Fit the original two 4GB CMX8GX3M2A133C9 sticks and re-test. If PC still fails to boot, will have to return to two sticks only and re-test with BIOS memory setting "Performance Enhancement" changed form "Turbo" to "Normal". If PC still fails to boot with 4 x 4GB in place, will have to re-test starting with two sticks only and enter BIOS to change "command rate" from 1T to 2T.