i have two fan on the rear, both inject the air in the case. I have one Fan in front wich is extracting the air.
It happen on an fresh install, i have only three drivers installed :
chipset intel 9.6.0.1014
Catalyst 10.6 and latest Crosfire Profile (i have HD5970)
and the sound driver, no whql version but works great on my other motherboard EP45-UD3P
No program in background, just i launch MediaPlayer classic, watching an episode of simpson and the pb occur
edit: only one PCI slot on this board