Hi,
Unlocking your 4th core is probably causing the problem.
The system could well be trying to access information on the Hard-drive but, the 4th core is unable to work properly (why it was locked off during manufacture) causing the Hard-drive to stutter and make weird noises.
The reason why it sometimes seems to BOOT OK is again, most certainly due to the faulty core on the CPU. Think about it. You don't unlock the core, everything's fine; You do unlock the core, you have problems.
AMD locked the core off because it didn't pass their Quality Control Checks and, if you try unlocking the core, there is no guarantee that it will work and, if it does, that it will be stable.