That's quite a bit of graphics horsepower for 5+ yr old hardware. I'd like to say it won't be a problem and will run at PCIe 2.0 spec, but we've seen some compatibility issues with older 55, 58 and 67 series chipsets when trying to run Gen 3 GPU's. I'd definitely upgrade to the latest BIOS available for the board if you plan to try. My preferred brand of GPUs is EVGA, but we all have our favorites.