Two things, first is your system 100% tested stable as you have it? You must be 100% stable for S3 to even work
And second, disable CPU PLL Overvoltage is not going to help, this will cause your overclock to fail. What I meant was since this gets disabled on resume from S3, you will need to use a lower CPU multiplier (Where you don't need CPU PLL Over), that way on resume from S3 it wont matter that the CPU PLL Overvolt has been disabled.
Some CPU's can do 42-45ish without it, others can do 46-50+ without it, you will just have to find the stable limit of your CPU without this setting enabled if you absolutely need S3 sleep for now.