I too have had the same problems. Essentially, with a Gigabyte GA-X58A-UD3R, the PSU I have (Zalman ZM-850) which is normally absolutely silent (which is why I bought it), begins squealing in any tasks such as scrolling the browser, loading windows or running the WEI test. It is particularly affected by Google Chrome.
I initially thought the problem was with the PSU, having read some other complaints about Zalman PSU's whining online. However, I then discovered this thread. I set the VCore voltage, I disabled C1E, and now the sound is 100% gone, meaning that this problem was absolutely a motherboard fault.
I, unlike other users, am quite happy to disable C1E if it stops the noise, so I will be leaving the system as is. I do believe that this fault on the motherboard needs to be resolved though.
Full spec:
MB: Gigabyte X58A-UD3R
CPU: i7-980 Extreme
CPU HS: Noctua NH-D14
RAM: 6GB Corsair Dominator 16000 (3 x 2 GB) for i7 processors
HD: OCZ Revodrive 240GB
GFX: Sapphire Vapor-X HD 5870
PSU: Zalman ZM-850
CASE: Silverstone Raven RV02
For anyone interested in the acoustics of the above system (each part selected for silence), it is inaudible during idle, the idle temps of the CPU are 23 degrees, and it gets 7.9 in every WEI measure.