Site states the following support.
200 Series
 (Only support PCH PCIe x4 slot)  Z270X-Gaming K7 Z270X-Gaming 5 Z270X-Gaming K5 Z270X-Ultra Gaming 
Z270-Gaming 3 Z270-Gaming K3 Z270MX-Gaming 5 Z270X-Designare 
Z270X-Gaming SOC H270-Gaming 3 Z270X-UD3 Z270XP-SLI