I have a rev 2.0 X58A-UD3R and thought I'd chime in. I just loaded windows and haven't really tried any normal use of the machine yet, but I immediately noticed a high pitched whine that does not change. It takes a couple seconds after powering on to make the sound, but then it's constant. I thought it may be a fan, but after reading most of the posts here, I believe it's the electrical noise problem. I don't buy into the whole test multiple power supplies, graphics cards, changing C1E and voltage settings (although I did change C1E and voltage anyway to no avail). I'm still at the original bios FA by the way. Anyway, as users, we shouldn't have to change our systems totally around and do without features like power saving, etc. to avoid this type of noise, especially if we are already using fairly high end, proven stuff. For $209, I expect a lot more. I'll be playing with the board, maybe update the bios tomorrow, but if the sound doesn't go away, I'll be RMAing this to newegg and seeing if I can avoid a restocking fee. If you look at the recent reviews at newegg in the past 2 weeks, most are very negative on this board.
My System
MB: GA X58A-UD3R
CPU: Core i7 930
PSU: Corsair HX850
GPU: Gigabyte GeForce GTX 460 OC